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KMID : 1003219990050010202
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Journal of Korean Oriental Chronic Disease
1999 Volume.5 No. 1 p.202 ~ p.218
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Effects of Herbal Medicine(DS-9801) on Ethanol-induced Gastric Mucosal Damage in Rats
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Abstract
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Our study used an ethanol as an inducing agent for gastric damage in the rat. All the rats were treated with either herbal medicine(DS-9801), following ethanol treatment for curing study or followed by ethanol administration for protective study. The rat stomachs were exposed, photographed and tissues were taken for microscopic observation.
The microscopic observation showed that DS-9801 administered group had smaller hemorrhagic erosion size than control group. The protective effect of DS-9801 against ulcer lasted until 36 hours and curing effect was significant at 30 minutes and 6 hours but there were much difference on its effect by time. The histrological observation revealed less deterioration of stomach mucosa layer by hemmorage, stomach mucosa layer in DS-9801 administered group than in control. Summing up those results suggest that DS-9801 administeration was effective in curing stomach ulcer and continuous further research works seem to necessary to reveal its functional mechanisms.
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